Mutation is the essence of multiplication.
The higher the numbers the more are the chances of Mutation( in other words deviation from normal genetics)1. Mendelians law:- Use it and imagine the different possibilities of obtaining a variant in humans or plants ( millions of genes to cross match)
2. Upcoming new viruses are occurring due to the same law. Most probable time is fertilization.( could be at macorcellular or micro- cellular level.)

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